Sanctum Sanctorum

Cinematic

2012 Defends the New York Sanctum and the Time Stone from Chitauri forces until the invasion is ended. (Ancient One, permalink)
2017 Strange enters the Dark Dimension and traps Dormammu in a time loop until he agrees to leave Earth alone, then becomes protector of the New York Sanctum. (Doctor Strange, permalink)
2017 Kaecilius and the Zealots destroy the London Sanctum and kill Sol Rama, then kill Daniel Drumm at the New York Sanctum. (Kaecilius, permalink)
2018 Thanos attacks the Statesman and beats Hulk, and Heimdall sends him by Bifrost to the New York Sanctum on Earth. (Hulk, permalink)
2024 Taken to the New York Sanctum, he learns from Sandman that he and Doctor Octopus both died fighting their Spider-Man, and is locked in a cell by Strange. (Norman Osborn (Green Goblin), permalink)

Silver After a car accident ended his surgical career, Strange travelled to Tibet, accepted the Ancient One's offer to teach him sorcery, and later took up residence in the Sanctum Sanctorum in New York. (Doctor Strange, permalink)
Modern Wong stays on to serve the New Avengers who shelter in Strange's Sanctum Sanctorum. (Wong, permalink)
Secret Wars After Hydra's takeover of the United States, Mordo is made caretaker of Manhattan and settles in the Sanctum Sanctorum. (Karl Mordo, permalink)
Fresh Start Strange was found stabbed to death by his old enemy Kaecilius at the Sanctum Sanctorum, leaving Earth without its magical barrier. (Doctor Strange, permalink)